NGEstrogen is a DNA test that will help you identify the individual genetic “settings” of your body associated with hormone estrogen processing. NGEstrogen testing is done once in a lifetime, and its results will allow you to adapt your regimen in a way that will reduce the genetic risk associated with the development of estrogen-dependent diseases. Based on the received information, you will be able to adapt your nutritional and physical regimen to the individual needs of your body and, if necessary, to start synthetic hormones and nutraceuticals intake.
Estrogen levels determine the way in which key biological processes occur in the body. Disturbed hormonal balance can lead to a number of estrogen-dependent diseases, including:
- Ovarian cysts;
- Fibroid tumors of the uterus;
- ER-positive breast cancer, uterine and ovarian cancer, prostate cancer;
- Fibrocystic and painful breasts;
- Cervical dysplasia;
- Systemic lupus erythematosus.
Hormonal imbalance is also among the main “culprits” for the premenstrual syndrome that accompanies a large proportion of women in their adulthood.
Once the test is done the obtained results will be valid throughout your life.
Obtaining a DNA sample is painless, doesn’t require taking blood and is completely safe procedure. It is done at home without the intervention of medical practitioner. All you have to do is rub the inside of your cheek with the sterile cotton swabs you will find in the test kit that you will receive when ordering a test.
The results of the study will be completed within 4 to 6 weeks from the date of sample submission. You will receive e-mail informing you of the way you can access them. The cost of the study includes consultation with genetics practitioner trained in the reading of the results to help you understand your genetic potential in detail and identify specific ways for its realization.
Based on the results, individual recommendations are developed to help you:
- To reduce the risk of developing estrogen-dependent diseases.
- To build a customized diet and physical regimen to help maintain optimal estrogen balance.
- To identify the individual risks of oral contraception and hormone replacement therapy.
- To assess the need for dietary supplements and nutraceuticals.
Depending on the variants of the individual genetic profile that each person has, the body is able to handle the estrogen metabolism in various ways. There are gene variants that are thought to cause difficulties in the process of estrogen metabolism and detoxification.
Identifying people who are carriers of such genetic variations allows them to make changes in their lifestyle according to their genetic profile, optimize estrogen uptake and create the conditions necessary for maintaining hormonal balance.
- If you have problems maintaining estrogen balance in your body.
- If you are undergoing hormone replacement therapy or taking hormones in the form of an oral contraceptive or other hormonal medications.
- If you want to reduce the risk of developing estrogen-dependent diseases and get the most out of your genetic potential.
- If you have in your family history estrogen-dependent diseases such as breast, uterine, ovarian or prostate cancer.
- If you are diagnosed with ER-positive cancer or are in remission of ER-positive disease and want to control estrogen levels in your body.
- If you are considering undergoing in vitro procedures.
- If you are diagnosed with ER-positive prostate cancer.
Tested genes function
- Metabolic estrogen pathway.
- Phases 1 and 2 of detoxification.
Genes tested and the influence of encoded proteins
- CYP1A1 – Encodes a phase 1 cytochrome P450 enzyme that converts pro-carcinogens from the environment into reactive mediators with carcinogenic effect. In addition, CYP1A1 is also involved in the oxidative metabolism of estrogens.
- CYP1B1 – Catalyzes the estradiol 4-hydration and activates many polycyclic aromatic hydrocarbons and arylamines.
- CYP17A – Catalyzes reactions involved in drug metabolism and cholesterol synthesis, steroids and other lipids; it is also an integral part of the pathway of estrogen metabolism.
- MnSOD – Provides antioxidant aid in the cell that is needed to reduce the oxidative damage caused by reactive estrogen metabolites.
- GSTM1 – Responsible for the elimination of xenobiotics, carcinogens and oxidative stress products, including reactive estrogen metabolites.
- GSTT1 – A family of proteins that catalyze the conjugation of reduced glutathione; are responsible for removing reactive products from estrogen metabolism.
- COMT – Helps control levels of certain hormones and participates in the methylation and deactivation of catechol estrogens.
- MTHFR – Plays key role in folate metabolism and directs food-borne folates to DNA synthesis or re-polymerization of homocysteine, a process by which homocysteine is converted back into methionine. Decreased enzyme activity of MTHFR is associated with an increased risk of breast cancer in pre-menopausal women with prolonged estrogen exposure.
- SULT1A1 – Involved in the deactivation of estrogens and bioactivation of heterocyclic amines and polycyclic aromatic hydrocarbons.
- NQO1 – Quinone reductase plays a major role in the detoxification of potentially mutagenic and carcinogenic quinones produced by tobacco smoke, food and estrogen metabolism.
- Factor V – Factor V Leiden mutation is characterized by weak anticoagulant responses to activated protein C and an increased risk of venous thrombosis.
Upon request of 3 or 4 genetic tests for the same person, you have the opportunity to get 20% discount on the price. The condition of discount is related to the technological process in genetic testing – part of the process is done only once, instead of several times. If you would like to take advantage of this option, please contact us before ordering.
Family Package – when ordering a minimum of 3 tests for three separate family members, you have the option of 10% discount. If you would like to take advantage of this option, please contact us before ordering.
*The results of the study are currently available in English only.