Personalized health care
The NGHealth test helps maintain good health and optimal physical form through personalized gene-based nutrition.
The test includes gene variants involved in eight major biological processes. These gene variations have a significant impact on our health and susceptibility to various chronic diseases. They play crucial role in several metabolic processes and are important factors for developing a number of chronic diseases that can be prevented by balanced diet and adequate lifestyle changes, including:
- Type II diabetes;
- Osteoporosis and rheumatism;
- Malignant diseases;
- Cardiovascular diseases;
- Insulin resistance;
- Overweight and obesity;
- Food reaction (intolerance to lactose, polyunsaturated fat metabolism (PUFA), caffeine susceptibility and iron overload);
- Bitter taste;
- Metabolism of alcohol.
The information you receive through the NGHealth test will allow you to make the best choice in choosing a diet and lifestyle, thus optimizing the prevention of diseases to which you have genetic predisposition.
Based on the results, individual recommendations are developed to help you:
- Make effective health prevention and reduce the risk of developing lifestyle-dependent diseases to which you have genetic predisposition;
- Optimize the treatment of diseases that you have already developed and which are influenced by your lifestyle;
- Understand how key metabolic processes occur in your body, such as vitamin absorption, insulin sensitivity, food reactions, and others;
- Build a healthy, genome-based diet;
- Determine the optimal amount and ratio of vitamins, minerals, phytochemicals, fat and carbohydrates to include in your diet;
- Determine the need for nutritional supplements intake to compensate deficiencies caused by certain genetic variants, if necessary.
- If you want to make informed decisions about your health and lifestyle.
- If you want to minimize the risk of developing a disease to which you have a genetic predisposition.
- If your family has lifestyle-related diseases that are transmitted “by inheritance”.
- If you have already developed a lifestyle-related chronic illness that does not respond well to general treatment recommendations.
- If you notice symptoms of a lifestyle-related illness that you want to delay or prevent.
- If you want to reduce the risk of complications, as well as the negative effects of an already and rare disease.
- If you want to maintain good health and physical shape, making the most of your genetic potential.
Diet and especially the metabolism of dietary fat play important role in the prevention of cardiovascular diseases. By determining how the fats in your diet interact with your genes, you can alter your diet and achieve optimal cardiac health.
Metabolism of Vitamin B
Group B vitamins, especially folate, play a major role in: energy metabolism; DNA synthesis and repair; cardiovascular disease and cancer prevention; neural tube defects. In addition, Group B vitamins provide significant part of the chemical compounds needed to protect our genes from DNA damage by the invasive processes occurring during the cell’s normal life. These vitamins, which include folate, vitamin B6 and B12, help synthesize new DNA for the constantly dividing and renewing cells.
Your body’s effectiveness of metabolizing these vitamins can be altered by your gene variations, thus, potentially you may need increasing the required daily doses.
Gene variations that affect the enzyme functions in phase 1 and 2 of detoxification can be identified. On the basis of the test results, malfunctions or deficiencies in the performance of these functions can be identified, which can be compensated by the intake of certain nutrients or additives.
Antioxidants protect the human body from free radicals. Free radicals are normal residual products of energy processes in the body. However, these molecules can damage DNA and proteins and are associated with many chronic diseases. Antioxidants are present in the body in the form of enzymes or other low-molecular-weight compounds but can also be consumed as part of variety of food products when needed, in the event of a genetic variation that impedes their function.
Antioxidants are exogenous (natural or synthetic) or endogenous compounds acting to reduce or diminish the oxidative stress. The natural antioxidant system can be enzymatic and non-enzymatic. Enzymatic antioxidants are superoxide dismutase, catalase, peroxidase, glutathione, glutathione reductase and some supporting enzymes. Non-enzymatic antioxidants are low-molecular-weight antioxidants (LMWA), which contain ascorbic acid, lipoic acid, polyphenols, vitamin C, vitamin E, selenium, zinc, beta carotene, carotene, taurine, hypotaurine.
The human body continually breaks down and rebuilds bone tissue. Your genes, diet and lifestyle (including exercise, smoking and alcohol consumption) are important factors in these processes. By determining how your genes affect the metabolism of calcium and vitamin D in your body, you can change your diet and lifestyle to keep your bone strength.
Inflammation represents the way the body reacts to injury, infection or allergies. Inflammatory processes are controlled by genes which are activated and deactivated when necessary. Sometimes, however, gene variations can cause a gene to remain active longer than necessary. Poor inflammation for an extended period of time is associated with cardiovascular diseases, obesity and diabetes. Certain nutrients may suppress the expression of similar genes.
Insulin resistance syndrome is a term that describes combination of diseases that have a common characteristic – anomalies in the way the body uses insulin to metabolize carbohydrates. These diseases include obesity, type II diabetes, hypertension, hypercholesterolemia and heart diseases.
In the case of insulin resistance, the body’s cells have reduced ability to react to the hormone insulin, which normally removes glucose from the bloodstream by regulating its penetration into the cells. The frequent occurrence of type II diabetes in some families is an indication of the genetic origin of this disease. However, environmental factors such as obesity and stagnant lifestyle are usually needed to unlock the expression of these genes.
Reaction to food and metabolism of iron
Different nutrients and food components in food can affect people in variable ways. New research in genetics suggests that certain genes can be tested to determine how one responds to a given food component. The areas of food reactions in this panel include: lactose intolerance, polyunsaturated fat metabolism (PUFA), caffeine susceptibility and iron overload.
Problems with iron metabolism can lead to both deficiency and iron overload in the human body. Iron deficiency occurs when the amount of iron after depletion of reserves is not sufficient to cover functional needs or when there is insufficient iron release from the reserves due to a particular chronic disease. Iron overload, on the other hand, may be due to too much iron intake or genetic predispositions causing hemochromatosis.
Once the test is done the obtained results will be valid throughout your life.
Obtaining a DNA sample is painless, doesn’t require taking blood and is completely safe procedure. It is done at home without the intervention of medical practitioner. All you have to do is rub the inside of your cheek with the sterile cotton swabs you will find in the test kit that you will receive when ordering a test.
The results of the study will be completed within 4 to 6 weeks from the date of sample submission. You will receive e-mail informing you of the way you can access them. The cost of the study includes consultation with genetics practitioner trained in the reading of the results to help you understand your genetic potential in detail and identify specific ways for its realization.
- LPL – Removes lipids from the blood stream by hydrolyzing triglycerides into free fatty acids.
- CETP – Plays key role in the metabolism of HDL-cholesterol and promotes the exchange of lipids between lipoproteins.
- APOC3 – Plays important role in cholesterol metabolism.
- APOE – Of great importance for the normal catabolism of triglyceride-rich lipoprotein components and affects the body’s need for antioxidants.
- PON1-192 – Encodes the glycoprotein enzyme paroxonase and its decreased activity is associated with metabolic syndrome and risk, atherosclerosis and coronary heart disease.
Vitamins B / Methylation
- MTHFR – Targets food folate to DNA synthesis or re-polymerization of homocysteine.
- MTR – Catalyzes the re-polymerization of homocysteine in methionine.
- COMT – Catalyzes the transfer of methyl group from S-adenosylmethiones to catecholamines, including neurotransmitters dopamine, epinephrine and norepinephrine.
- MTRR – Catalyzes methylcobalamin, which is vital for maintaining sufficient intracellular stores of methionine. Maintains homocysteine concentrations at nontoxic levels.
- CBS – Catalyzes the conversion of homocysteine into cystathionine and participates directly in the removal of the homocysteine of the methionine cycle.
- CYP1A1 – Encodes a phase 1 cytochrome P450 enzyme that converts pro-carcinogens from the environment into reactive messengers with carcinogenic effect. In addition, CYP1A1 is also involved in the oxidative metabolism of estrogens.
- GSTM1 – Plays key role in phase 2 of detoxification. Removes xenobiotics, carcinogens, and oxidative stress products.
- GSTP1 – Affects the metabolism of many carcinogenic substances.
- GSTT1 – Member of larger family of proteins that catalyzes the conjugation of reduced glutathione.
- NQO1 – Quinone reductase plays a major role in the detoxification of potentially mutagenic and carcinogenic quinones obtained from tobacco smoke, food and estrogen metabolism.
- IL-6 – Plays a critical role in inflammatory processes by regulating C-reactive protein (CRP) expression.
- TNF-α – Inflammatory cytokine secreted by macrophages and adipocytes that alters glucose homeostasis throughout the body and plays a role in obesity associated with insulin resistance and dyslipidemia.
- IL-1A, IL-1B, IL-1RN – The IL-1 gene has 3 variants, each of which is interpreted differently. Genetic variations in IL-1A, IL-1B and IL-1RN lead to a more active response to inflammation and are associated with increased risk of certain chronic diseases.
Response and sensitivity to food
- MCM6 – Associated with lactose intolerance in adults.
- FADS1 – Influenceс blood fat concentration as an effect on the efficiency of desaturase enzyme.
- CYP1A2 – Affects the ability to metabolize caffeine.
- ACE & AGT – Part of the renin-angiotensin system; regulates the reaction to salt.
Overloading with iron
- HFE – Regulates iron absorption by managing integration of the transfer receptor with transferrin. Hereditary hemochromatosis results from defects in the HFE gene.
- eNOS – Affects vascular tone and peripheral vascular resistance. It also protects blood vessels by suppressing platelet aggregation, light-cell adhesion, and proliferation of smooth muscle cells.
- MnSOD/SOD2 – Vital antioxidant role in the cell, especially in mitochondria. Destroys the radicals that are usually produced in the cells.
- GPX1 – Encodes the GPX1 enzyme that appears in almost all body tissues and catalyzes the conversion of hydrogen peroxide (H2O2) into water (H2O) and is responsible for redox-balance.
- CAT-262 – Codes the antioxidant enzyme catalysis (CAT), which is responsible for the rapid conversion of hydrogen peroxide into water and oxygen. Plays crucial role in redox-balance; the reduced CAT activity leads to increased concentration of hydrogen peroxide and therefore to oxidative stress.
- VDR – Very important for bone density.
- COL1A1 – Affects the proportions of collagen-alpha chains synthesized in bone cells by affecting bone mineralization and strength.
- PPARG – Participates in adipocyte differentiation. It is a fatty acid-activated transcription factor involved in regulating glucose and lipid metabolism.
- TCF7L2 – Influences glucose homeostasis in blood, affecting insulin secretion and resistance.
- FTO – Affects obesity and the risk of type II diabetes.
- SLC2A2 – Facilitates the first step in insulin secretion caused by glucose and participates in the intake and regulation of food.
- TAS2R38 (bitter taste – type 2 sapictive/taste receptor gene 38) – The bitter taste is based on the ability to distinguish PTH and propylthiouracil (PROP). Greater sensitivity to bitter components in food may affect the amount of sugar intake.
Metabolism of alcohol
- ALDH2 – Aldehyde dehydrogenase 2 (ALDH2) is an enzyme that is expressed in the liver and converts toxic, carcinogenic aldehydes in acetate. This enzyme plays key role in protecting against oxidative stress.
Upon request of 3 or 4 genetic tests for the same person, you have the opportunity to get 20% discount on the price. The condition of discount is related to the technological process in genetic testing – part of the process is done only once, instead of several times. If you would like to take advantage of this option, please contact us before ordering.
Family Package – when ordering a minimum of 3 tests for three separate family members, you have the option of 10% discount. If you would like to take advantage of this option, please contact us before ordering.
*The results of the study are currently available in English only.